Medical Therapy of Brain Edema in Fulminant Hepatic Failure

Pathophysiology of cerebral edema in fulminant hepatic failure.

F hepatic failure (FHF) is a devastating disease and is still associated with a high mortality (1). FHF results in progressive multi-organ failure with a dramatic impact on the brain. Indeed, development of intracranial hypertension (IH) is a leading cause of death in FHF. During this decade two theories have independently emerged to explain the pathogenesis of cerebral edema and intrac...

Glyphosate Poisoning with Acute Fulminant Hepatic Failure

Background: Glyphosate containing herbicides are widely used the world over. They are marketed as nontoxic to humans, but numerous studies have showed that these glyphosate-based herbicides (GlySH) can cause multiorgan damage.1 Recent reports of animal studies on rats have raised a doubt of liver damage after long term exposure to GlySH. Case Presentation: a young male had chronic exposure to G...

Spontaneous Resolution of Brain Edema in Fulminant Hepatic Failure due to Hepatitis E

Fulminant hepatic failure is characterized by the presence of hepatic encephalopathy in the setting of acute liver injury that occurs in a noncirrhotic organ. Brain edema is the ultimate complication of advanced hepatic encephalopathy as it often leads to cerebral herniation and death. Thus, the presence of fulminant hepatic failure indicates the need for urgent liver transplantation to prevent...

Brain edema and intracranial hypertension in fulminant hepatic failure: pathophysiology and management.

Intracranial hypertension is a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure. The etiology of this intracranial hypertension is not fully determined, and is probably multifactorial, combining a cytotoxic brain edema due to the astrocytic accumulation of glutamine, and an increase in cerebral blood volume and cerebral blood flow, in part due to infla...

Fulminant hepatic failure due to metastatic choroidal melanoma